445 Dithranol in psoriasis: Keratinocyte-neutrophil crosstalk and TREM1 signaling

Evidence that a neutrophil–keratinocyte crosstalk is an early target of IL-17A inhibition in psoriasis

The response of psoriasis to antibodies targeting the interleukin (IL)-23/IL-17A pathway suggests a prominent role of T-helper type-17 (Th17) cells in this disease. We examined the clinical and immunological response patterns of 100 subjects with moderate-to-severe psoriasis receiving 3 different intravenous dosing regimens of the anti-IL-17A antibody secukinumab (1 × 3 mg/kg or 1 × 10 mg/kg on...

-patient treatment with calcipotriol versus dithranol in refractory psoriasis

IL-36γ inhibits differentiation and induces inflammation of keratinocyte via Wnt signaling pathway in psoriasis

Psoriasis is a common inflammatory skin disease characterized by abnormal keratinocyte inflammation and differentiation that has a major impact on patients' quality of life. IL-36γ, a member of IL-36 cytokine family, is highly expressed in psoriasis and plays an important role in inflammation response and differentiation. However, the function of IL-36γ in differentiation and inflammation of ke...

Microparticles facilitate neutrophil/platelet crosstalk.

In this issue of Blood, Pluskota and colleagues reveal a new prothrombotic pathway initiated by neutrophil-derived microparticles through the interaction of the leukocyte integrin Mac-1 ( M 2) on microparticles with its counterreceptor on platelets, GPIb , the major ligand-binding subunit of the GPIb-IX-V complex (see figure). These findings have broad implications for the pathogenesis, monitor...

Network Crosstalk Dynamically Changes during Neutrophil Polarization

How complex signaling networks shape highly coordinated, multistep cellular responses is poorly understood. Here, we made use of a network-perturbation approach to investigate causal influences, or "crosstalk," among signaling modules involved in the cytoskeletal response of neutrophils to chemoattractant. We quantified the intensity and polarity of cytoskeletal marker proteins over time to cha...